PT-141 (Spray)

PT-141, also known as Bremelanotide, is a synthetic cyclic heptapeptide developed as a metabolically stable analog of alpha-melanocyte stimulating hormone (alpha-MSH). Unlike phosphodiesterase inhibitors that act peripherally on vascular tissue, PT-141 operates centrally through the melanocortin receptor system. PT-141 demonstrates binding affinity for melanocortin receptors, particularly the melanocortin-4 receptor (MC4R), making it a valuable tool for investigating receptor subtype pharmacology. The cyclic lactam structure confers enhanced metabolic stability compared to linear peptide analogs, enabling longer-lasting receptor engagement in laboratory research models.

Chemical Structure and Identification

• Molecular Formula: C₅₀H₆₈N₁₄O₁₀
• Molecular Weight: 1025.16 g/mol
• CAS Number: 189691-06-3

Research Applications

• Melanocortin Receptor Pharmacology: Investigation of PT-141’s binding affinity and agonist activity at MC3R and MC4R [1]
• Central Nervous System Signaling: Examination of PT-141’s effects on hypothalamic receptor-mediated pathways [2]
• Peptide Structure-Activity Relationships: Study of cyclic lactam peptide configurations and their impact on receptor engagement [3]
• Receptor Subtype Selectivity: Comparison of PT-141’s binding and activation profiles across melanocortin receptor subtypes [4]

Reference Citations

1. PubChem CID 9941379 | https://pubchem.ncbi.nlm.nih.gov/compound/9941379
2. Molinoff PB et al. (2003) – Ann N Y Acad Sci | https://pubmed.ncbi.nlm.nih.gov/
3. PMC6711436 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6711436/
4. Yang Y (2011) – Curr Top Med Chem | https://pubmed.ncbi.nlm.nih.gov/

Important Regulatory Notice

These products are for research use only and are not intended for human consumption, therapeutic use, or diagnostic purposes. All compounds described herein have not been approved by the FDA for human use. These products are strictly intended for in vitro laboratory research and analytical purposes when conducted by qualified research professionals in licensed facilities. Users are responsible for ensuring compliance with all applicable laws regarding purchase and use of these materials.