Melanotan II (Spray)

Melanotan II is a synthetic cyclic heptapeptide developed as a potent, stable analog of alpha-melanocyte stimulating hormone (alpha-MSH). The compound structure Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2 incorporates a cyclic lactam configuration that confers enhanced resistance to enzymatic degradation and extended biological activity compared to the linear parent hormone. Melanotan II functions as a potent full agonist at melanocortin-3 receptor (MC3R) and melanocortin-4 receptor (MC4R). Research has characterized this compound’s activity at the melanocortin receptor system, including melanogenesis stimulation, appetite suppression, and neuroprotective effects.

Chemical Structure and Identification

• Molecular Formula: C₅₀H₆₉N₁₅O₉
• Molecular Weight: 1024.2 g/mol
• CAS Number: 121062-08-6

Research Applications

• Melanocortin Receptor Pharmacology: Investigation of Melanotan II’s potent agonist activity at MC3R and MC4R [1]
• Melanogenesis Research: Examination of Melanotan II’s effects on melanocyte activation and melanin synthesis pathways [2]
• Appetite and Energy Regulation: Study of Melanotan II’s impact on hypothalamic MC4R-mediated food intake signaling [3]
• Neuroprotective Mechanisms: Exploration of Melanotan II’s potential melanocortin receptor-mediated neuroprotective effects [4]

Reference Citations

1. PubChem CID 92432 | https://pubchem.ncbi.nlm.nih.gov/compound/92432
2. Dorr RT et al. (1996) – Life Sci | https://pubmed.ncbi.nlm.nih.gov/
3. PMC1565291 | https://pmc.ncbi.nlm.nih.gov/articles/PMC1565291/
4. Giuliani D et al. (2007) – Eur J Pharmacol | https://pubmed.ncbi.nlm.nih.gov/

Important Regulatory Notice

These products are for research use only and are not intended for human consumption, therapeutic use, or diagnostic purposes. All compounds described herein have not been approved by the FDA for human use. These products are strictly intended for in vitro laboratory research and analytical purposes when conducted by qualified research professionals in licensed facilities. Users are responsible for ensuring compliance with all applicable laws regarding purchase and use of these materials.