Selank (Spray)

Selank is a synthetic heptapeptide designed as a stabilized version of the naturally occurring immunomodulatory tetrapeptide tuftsin. Comprising a seven amino acid sequence (Thr-Lys-Pro-Arg-Pro-Gly-Pro) with an added Pro-Gly-Pro tripeptide extension for enhanced stability, Selank is notable for its ability to cross the blood-brain barrier. Research has identified Selank as a unique compound with distinct mechanisms of action, setting it apart from traditional pathways. Ideal for research purposes, it offers a fascinating avenue for exploration in peptide studies.

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Selank is a synthetic heptapeptide developed as a stabilized analog of the endogenous immunomodulatory tetrapeptide tuftsin. The peptide comprises a seven amino acid sequence (Thr-Lys-Pro-Arg-Pro-Gly-Pro) with the addition of a Pro-Gly-Pro tripeptide extension at the C-terminus that enhances enzymatic stability and prolongs biological activity. Selank demonstrates the ability to cross the blood-brain barrier and exert direct modulatory effects on central nervous system signaling. Research has characterized Selank as a compound with anxiolytic properties that operates through mechanisms distinct from classical benzodiazepine pathways.

Chemical Structure and Identification

  • Molecular Formula: C₃₃H₅₇N₁₁O₉
  • Molecular Weight: 751.88 g/mol
  • CAS Number: 129954-34-3

Research Applications

  • Anxiolytic Mechanism Research: Investigation of Selank’s effects on GABAergic and serotonergic pathways in neuronal systems [1]
  • Neuropeptide Signaling: Examination of Selank’s impact on hippocampal inhibitory postsynaptic currents and neurotransmission [2]
  • Cytokine Regulation: Study of Selank’s anti-inflammatory properties and modulation of pro-inflammatory mediators [3]
  • Peptide Stability and Delivery: Evaluation of Selank’s enzymatic degradation resistance and blood-brain barrier permeability [4]

Reference Citations

  1. PMC4598447 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4598447/
  2. Kozlovskaya MM et al. (2003) – Eur J Pharmacol | https://pubmed.ncbi.nlm.nih.gov/
  3. PubChem CID 11765600 | https://pubchem.ncbi.nlm.nih.gov/compound/11765600
  4. PMC4851508 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4851508/

Important Regulatory Notice

These products are for research use only and are not intended for human consumption, therapeutic use, or diagnostic purposes. All compounds described herein have not been approved by the FDA for human use. These products are strictly intended for in vitro laboratory research and analytical purposes when conducted by qualified research professionals in licensed facilities. Users are responsible for ensuring compliance with all applicable laws regarding purchase and use of these materials.

Important Regulatory Notice

These products are for research use only and are not intended for human consumption, therapeutic use, or diagnostic purposes. All compounds described herein have not been approved by the FDA for human use. These products are strictly intended for in vitro laboratory research and analytical purposes when conducted by qualified research professionals in licensed facilities. Users are responsible for ensuring compliance with all applicable laws regarding purchase and use of these materials.