Tesamorelin

Tesamorelin is a stabilized synthetic analogue of human growth hormone-releasing hormone (GHRH 1-44) that incorporates a trans-3-hexenoic acid modification at the N-terminal tyrosine residue, which substantially extends its half-life relative to endogenous GHRH. It binds directly to pituitary GHRH receptors to stimulate the synthesis and pulsatile release of endogenous growth hormone. Tesamorelin is FDA-approved (as Egrifta SV) for the treatment of excess abdominal fat in HIV-infected patients with lipodystrophy. In research settings, it is studied as a precise tool for stimulating physiological GH secretion, investigating the GHRH-GH-IGF-1 axis, and examining visceral adipose tissue regulation, lipid metabolism, and cognitive function in preclinical and clinical models. For research use only. Not for human consumption.

Chemical Structure and Identification

• Molecular Formula: C₂₂₁H₃₆₆N₇₂O₆₇S
• Molecular Weight: 5135.86 g/mol
• CAS Number: 218949-48-5

Research Applications

• GH Axis and Pituitary Research: Investigation of tesamorelin’s stimulation of pulsatile GH secretion via GHRH receptor binding, downstream IGF-1 axis regulation, and pituitary somatotroph function models [1]
• Visceral Adipose Tissue Research: Study of GHRH-analogue-mediated reductions in visceral fat accumulation, lipid metabolism changes, and adipokine signaling in lipodystrophy and metabolic research models [2]
• Cognitive Function Research: Examination of tesamorelin’s effects on IGF-1-mediated cognitive outcomes, memory, and brain morphology in aging and HIV-associated neurocognitive disorder models [3]
• Lipid Metabolism and Cardiovascular Research: Analysis of GH secretagogue effects on triglyceride levels, LDL particle size, and cardiovascular risk markers in preclinical and early clinical study models [4]

Reference Citations

1. Falutz J et al. (2007) – N Engl J Med | https://pubmed.ncbi.nlm.nih.gov/17715410/
2. Stanley TL et al. (2012) – J Clin Endocrinol Metab | https://pubmed.ncbi.nlm.nih.gov/22162476/
3. Sevigny JJ et al. (2012) – Neurology | https://pubmed.ncbi.nlm.nih.gov/22302543/
4. Dhillon S (2011) – Drugs | https://pubmed.ncbi.nlm.nih.gov/21443285/

Important Regulatory Notice

These products are for research use only and are not intended for human consumption, therapeutic use, or diagnostic purposes. All compounds described herein have not been approved by the FDA for human use. These products are strictly intended for in vitro laboratory research and analytical purposes when conducted by qualified research professionals in licensed facilities. Users are responsible for ensuring compliance with all applicable laws regarding purchase and use of these materials.