SR-9009 (Capsules)

SR-9009, commonly known as Stenabolic, is a synthetic small-molecule agonist of the nuclear receptor REV-ERBα (NR1D1/NR1D2). Developed at the Scripps Research Institute as a research tool compound for investigating circadian rhythm biology and metabolic regulation [1], SR-9009 acts as a transcriptional repressor binding to the REV-ERB ligand-binding domain. REV-ERBα plays a central role in regulating circadian clock functions, lipid metabolism, glucose handling, mitochondrial biogenesis, and energy expenditure. The compound demonstrates selective activation of REV-ERB signaling pathways with reported IC50 values of 670 nM for REV-ERBα and 800 nM for REV-ERBβ, making it a valuable tool for mechanistic studies of nuclear receptor pharmacology in controlled research settings.

Chemical Structure and Identification

• Compound Name: SR-9009 (Stenabolic)
• Per Capsule: 10 mg per capsule
• Molecular Formula: C₂₀H₂₄ClN₃O₄S
• Molecular Weight: 437.94 g/mol
• CAS Number: 1379686-30-2

Research Applications

• Circadian Rhythm Research: Investigation of REV-ERB’s role in circadian oscillation, core clock gene expression, and temporal biological regulation [1]
• Metabolic Signaling Studies: Examination of glucose homeostasis, lipid metabolism, and dyslipidemia in preclinical models [2]
• Mitochondrial Biogenesis: Research into mitochondrial function enhancement, energy expenditure mechanisms, and cellular respiration [1]
• Nuclear Receptor Pharmacology: Mechanistic evaluation of REV-ERB ligand-dependent transcriptional regulation and gene expression patterns [3]
• Inflammatory Response Pathways: Investigation of REV-ERB-mediated immune modulation and inflammatory gene suppression [2]

Reference Citations

1. Scripps Research Institute – Original compound development and characterization as REV-ERBα agonist with defined binding kinetics | https://pubmed.ncbi.nlm.nih.gov/
2. PubMed Database – Comprehensive studies on SR-9009 effects on circadian locomotor activity and hypothalamic clock gene expression | https://pubmed.ncbi.nlm.nih.gov/
3. International Journal of Molecular Sciences – In vitro metabolic studies of REV-ERB agonists including SR-9009 and SR-9011 compound families | https://pubmed.ncbi.nlm.nih.gov/

Important Regulatory Notice

These products are for research use only and are not intended for human consumption, therapeutic use, or diagnostic purposes. All compounds described herein have not been approved by the FDA for human use. These products are strictly intended for in vitro laboratory research and analytical purposes when conducted by qualified research professionals in licensed facilities. Users are responsible for ensuring compliance with all applicable laws regarding purchase and use of these materials.