SLU-PP-332 (Capsules)

SLU-PP-332 is a synthetic estrogen-related receptor (ERR) pan-agonist developed at Saint Louis University for mechanistic research into metabolic signaling and exercise-mimetic responses [1]. This small-molecule compound selectively activates estrogen-related receptors alpha, beta, and gamma, with differential EC50 values reflecting its broad ERR activity profile. Unlike direct GH secretagogues or mitochondrial uncouplers, SLU-PP-332 activates cellular pathways that coordinate metabolic adaptation to endurance training [2]. The compound demonstrates oral bioavailability and has been studied in preclinical models for its effects on energy expenditure, mitochondrial biogenesis, and metabolic flexibility. Research applications focus on understanding ERR-mediated metabolic signaling without affecting estrogen receptors, making it a valuable tool for selective nuclear receptor research.

Chemical Structure and Identification

• Compound Name: SLU-PP-332 (ERR Pan-Agonist)
• Per Capsule: 250 mcgs per Capsule
• Molecular Formula: C₁₈H₁₄N₂O₂
• Molecular Weight: 290.32 g/mol
• CAS Number: 303760-60-3

Research Applications

• Exercise Mimetic Research: Investigation of ERR-mediated cellular adaptations to endurance training-like stimuli without physical exertion [1][2]
• Metabolic Flexibility: Examination of oxidative fiber composition enhancement and fatty acid oxidation capacity [2]
• Mitochondrial Biogenesis: Research into mitochondrial density increase and cellular respiration capacity [1]
• Energy Expenditure Mechanisms: Mechanistic studies of ERR agonism effects on cellular energy utilization and metabolic rate [2]
• Nuclear Receptor Selectivity: Evaluation of ERR pathway activation independent of estrogen receptor signaling [1]

Reference Citations

1. University of Florida/ACS Chemical Biology (2023) – Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity | https://pubmed.ncbi.nlm.nih.gov/
2. Cell Metabolism/Billon et al. (2022) – Estrogen-Related Receptor Agonist Effects on Exercise Capacity and Metabolic Phenotype | https://pmc.ncbi.nlm.nih.gov/

Important Regulatory Notice

These products are for research use only and are not intended for human consumption, therapeutic use, or diagnostic purposes. All compounds described herein have not been approved by the FDA for human use. These products are strictly intended for in vitro laboratory research and analytical purposes when conducted by qualified research professionals in licensed facilities. Users are responsible for ensuring compliance with all applicable laws regarding purchase and use of these materials.