Selank

Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) developed from the human immunoglobulin G-derived tetrapeptide tuftsin, with a C-terminal Pro-Gly-Pro extension added to enhance metabolic stability and duration of action. Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, Selank has been studied extensively for anxiolytic, nootropic, and immunomodulatory properties in preclinical and early clinical settings. Its proposed mechanisms include allosteric modulation of GABA-A receptors, regulation of BDNF and enkephalin expression, and modulation of cytokine profiles during stress conditions. It exhibits anxiolytic activity comparable to low-dose benzodiazepines in rodent models without the characteristic sedation, dependence, or memory impairment. For research use only. Not for human consumption.

Chemical Structure and Identification

• Molecular Formula: C₃₃H₅₇N₁₁O₉
• Molecular Weight: 751.88 g/mol
• CAS Number: 129954-34-3

Research Applications

• Anxiety and Stress Neuropharmacology: Investigation of Selank’s GABA-A receptor allosteric modulation and its anxiolytic effects in acute stress, chronic mild stress, and withdrawal models in rodents [1]
• Nootropic and Cognitive Research: Study of Selank’s effects on memory formation, learning consolidation, and hippocampal BDNF expression in preclinical behavioral models [2]
• Immunomodulatory Research: Examination of Selank’s influence on cytokine levels, particularly IL-2, IL-6, and interferon-gamma, in social stress and inflammatory preclinical models [3]
• Opioid and Substance Dependence Models: Analysis of Selank’s ability to attenuate morphine withdrawal signs and modify opioid-related behavior in rat naloxone-precipitation models [4]

Reference Citations

1. Zolotarev YA et al. (2019) – Curr Pharm Des | https://pubmed.ncbi.nlm.nih.gov/30255741/
2. Semenova TP et al. (2010) – Bull Exp Biol Med | https://pubmed.ncbi.nlm.nih.gov/20938505/
3. PMC5322660 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5322660/
4. Vyunova TV et al. (2018) – Acta Naturae | https://pubmed.ncbi.nlm.nih.gov/29511588/

Important Regulatory Notice

These products are for research use only and are not intended for human consumption, therapeutic use, or diagnostic purposes. All compounds described herein have not been approved by the FDA for human use. These products are strictly intended for in vitro laboratory research and analytical purposes when conducted by qualified research professionals in licensed facilities. Users are responsible for ensuring compliance with all applicable laws regarding purchase and use of these materials.