HGH-Frag 176-191

HGH Fragment 176-191 is a synthetic peptide representing the C-terminal amino acid sequence from position 176 to 191 of human growth hormone (hGH). This fragment includes a tyrosine-to-phenylalanine substitution at the terminal position and contains an internal disulfide bond. It is primarily studied for its involvement in lipolytic signaling, having demonstrated anti-insulin activity and the capacity to influence fatty acid metabolism in preclinical rodent models. Unlike full-length hGH, HGH Fragment 176-191 lacks growth-promoting activity, making it a useful research tool for isolating and studying the metabolic functions of the GH C-terminal domain. Research has also explored its interaction with cancer cell lines and chitosan nanoparticle drug delivery systems. This product is for laboratory research use only and is not intended for human consumption.

Chemical Structure and Identification

• Molecular Formula: C₇₈H₁₂₃N₂₃O₂₂S₂
• Molecular Weight: 1799.1 g/mol
• CAS Number: 66004-57-7

Research Applications

• Lipid Metabolism and Lipolysis Research: Study of the peptide’s anti-insulin activity and its effects on fatty acid utilization and lipolytic signaling in obese rodent models [1]
• Cancer Cell Biology: Investigation of HGH Fragment 176-191 in combination with doxorubicin-loaded chitosan nanoparticles against breast cancer cell lines including MCF-7 [2]
• Growth Hormone Fragment Pharmacology: Comparative examination of C-terminal hGH fragments to delineate metabolic versus somatogenic functions of growth hormone domains [3]
• Metabolic Syndrome Models: Use of this fragment as a molecular tool to probe GH-related adipose tissue regulation and glucose homeostasis pathways [4]

Reference Citations

1. Ng FM et al. (1990) – J Mol Endocrinol | https://pubmed.ncbi.nlm.nih.gov/2090147/
2. Habibullah MM et al. (2022) – Drug Des Devel Ther | https://pmc.ncbi.nlm.nih.gov/articles/PMC9249349/
3. Heffernan MA et al. (2001) – J Clin Endocrinol Metab | https://pubmed.ncbi.nlm.nih.gov/11238497/
4. Ng FM et al. (1978) – Am J Physiol | https://pubmed.ncbi.nlm.nih.gov/357237/

Important Regulatory Notice

These products are for research use only and are not intended for human consumption, therapeutic use, or diagnostic purposes. All compounds described herein have not been approved by the FDA for human use. These products are strictly intended for in vitro laboratory research and analytical purposes when conducted by qualified research professionals in licensed facilities. Users are responsible for ensuring compliance with all applicable laws regarding purchase and use of these materials.