DSIP

Delta Sleep-Inducing Peptide (DSIP) is a synthetic nonapeptide originally isolated from the cerebral venous blood of rabbits during slow-wave sleep. Comprising a nine amino acid sequence (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu), DSIP demonstrates the ability to cross the blood-brain barrier, making it a valuable research compound for investigating neuromodulatory mechanisms. The peptide is found in plasma, peripheral organs, and neurons, with research indicating its concentrations correlate with human circadian rhythm patterns and sleep initiation. DSIP exhibits biological activities beyond sleep modulation, including interaction with neurotransmitter release systems, hormonal regulation pathways, and stress response mechanisms. Research has identified altered DSIP concentrations in the cerebrospinal fluid and plasma of subjects with neuropsychiatric conditions, positioning it as a valuable molecular probe for investigating neurological signaling, circadian biology, and stress-protective biochemical cascades in cell culture systems.

Chemical Structure and Identification

• Molecular Formula: C₃₅H₄₈N₁₀O₁₅
• Molecular Weight: 848.82 g/mol
• CAS Number: 62568-57-4

Research Applications

• Sleep Regulation Mechanisms: Investigation of DSIP’s neuromodulatory activity on slow-wave sleep induction and circadian rhythm signaling [1]
• Neurotransmitter Modulation: Examination of DSIP’s effects on serotonin, dopamine, and norepinephrine release pathways [2]
• Stress Response Pathways: Exploration of DSIP’s stress-protective biochemical mechanisms and effects on corticosterone regulation [3]
• Neuroprotection Research: Study of DSIP’s antioxidant and immunomodulatory activity in neurological cell culture models [4]

Reference Citations

1. Schoenenberger GA, Monnier M (1977) – Proc Natl Acad Sci USA | https://pubmed.ncbi.nlm.nih.gov/
2. PubChem CID 68816 | https://pubchem.ncbi.nlm.nih.gov/compound/68816
3. Khvatova EM et al. (2003) – Neurosci Behav Physiol | https://pubmed.ncbi.nlm.nih.gov/
4. PMC1190736 | https://pmc.ncbi.nlm.nih.gov/articles/PMC1190736/

Important Regulatory Notice

These products are for research use only and are not intended for human consumption, therapeutic use, or diagnostic purposes. All compounds described herein have not been approved by the FDA for human use. These products are strictly intended for in vitro laboratory research and analytical purposes when conducted by qualified research professionals in licensed facilities. Users are responsible for ensuring compliance with all applicable laws regarding purchase and use of these materials.