CJC w/Dac

CJC-1295 with DAC is a synthetic analog of growth hormone-releasing hormone (GHRH) engineered to have an extended half-life and enhanced bioavailability compared to endogenous GHRH. The 30-amino acid peptide incorporates the initial 29 residues of GHRH and a Glu-Ser-Ser linker to a reactive Cys residue, allowing for covalent bonding to albumin through a maleimide group. This conjugation creates a drug affinity complex that protects the peptide from degradation and prolongs its circulation time, resulting in sustained GH release and elevated IGF-1 levels. CJC-1295 with DAC has been studied for its potential to treat GH deficiency, reverse age-related declines in GH production, and improve body composition. The peptide’s extended activity provides a valuable tool for investigating the long-term effects of GHRH receptor activation and GH/IGF-1 axis modulation.

Chemical Structure and Identification

• Molecular Formula: C₁₆₅H₂₆₉N₅₁O₅₀S
• Molecular Weight: 3780.16 g/mol

Research Applications

• Growth Hormone Axis Regulation: Examination of CJC-1295 with DAC’s effects on GHRH receptor signaling and downstream GH and IGF-1 production [1]
• Aging and Metabolic Research: Investigation of the peptide’s impact on age-related changes in body composition, metabolism, and GH/IGF-1 levels [2]
• Peptide Half-Life Extension: Study of the drug affinity complex’s effects on peptide pharmacokinetics and stability [1]
• Receptor Activation Kinetics: Comparison of sustained versus pulsatile GHRH receptor activation on GH pulsatility and physiological outcomes [3]

Reference Citations

1. PMC4159583 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4159583/
2. Cooper SA et al. (2020) – J Gerontol A Biol Sci Med Sci | https://pubmed.ncbi.nlm.nih.gov/32227174/
3. Ionescu M, Frohman LA (2006) – Pituitary | https://pubmed.ncbi.nlm.nih.gov/17308359/

Important Regulatory Notice

These products are for research use only and are not intended for human consumption, therapeutic use, or diagnostic purposes. All compounds described herein have not been approved by the FDA for human use. These products are strictly intended for in vitro laboratory research and analytical purposes when conducted by qualified research professionals in licensed facilities. Users are responsible for ensuring compliance with all applicable laws regarding purchase and use of these materials.