CJC-1295 No DAC Ipamorelin

The 2X Blend features CJC-1295 without DAC and Ipamorelin, two synthetic peptides that work together to stimulate growth hormone secretion. CJC-1295, a 30-amino acid peptide, binds to GHRH receptors to induce GH release and IGF-1 production, while its DAC-free form ensures a prolonged half-life. Ipamorelin, a pentapeptide, selectively targets the ghrelin/growth hormone secretagogue receptor, boosting GH release without influencing prolactin, cortisol, or TSH levels. This powerful combination is ideal for exploring the neuroendocrine regulation of the somatotropic axis.

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The 2X Blend combines CJC-1295 without DAC and Ipamorelin, two synthetic peptides that work synergistically to stimulate growth hormone secretion. CJC-1295 is a 30-amino acid peptide and analog of growth hormone-releasing hormone (GHRH) that binds to GHRH receptors in the pituitary, inducing GH release and IGF-1 production. The exclusion of DAC prolongs the half-life while maintaining physiological GH pulsatility. Ipamorelin is a pentapeptide selective agonist of the ghrelin/growth hormone secretagogue receptor (GHS-R1a) that enhances GH release without affecting prolactin, cortisol, or TSH levels. The combination of a GHRH analog and ghrelin mimetic produces a substantial GH response for investigating the neuroendocrine regulation of the somatotropic axis.

Chemical Structure and Identification

  • Molecular Formula: C₁₅₂H₂₅₂N₄₄O₄₂
  • Molecular Weight: 3367.95 g/mol
  • Molecular Formula: C₃₈H₄₉N₉O₅
  • Molecular Weight: 711.85 g/mol
  • CAS Number: 170851-70-4

Research Applications

  • Growth Hormone Regulation: Examination of GHRH and ghrelin receptor agonist synergy on somatotropic axis signaling [1]
  • Neuroendocrine Signaling: Investigation of hypothalamic-pituitary pathways controlling GH pulsatility and IGF-1 production [2]
  • Aging and Metabolism Research: Study of GH/IGF-1 axis changes, body composition, and metabolic parameters in aging models [1]
  • Receptor Pharmacology: Comparative analysis of GHRH and GHS-R1a activation and downstream effectors [3]

Reference Citations

  1. PMC4703316 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4703316/
  2. Ionescu M, Frohman LA (2006) – Pituitary | https://pubmed.ncbi.nlm.nih.gov/17308359/
  3. PubChem CID 9832414 | https://pubchem.ncbi.nlm.nih.gov/compound/Ipamorelin

Important Regulatory Notice

These products are for research use only and are not intended for human consumption, therapeutic use, or diagnostic purposes. All compounds described herein have not been approved by the FDA for human use. These products are strictly intended for in vitro laboratory research and analytical purposes when conducted by qualified research professionals in licensed facilities. Users are responsible for ensuring compliance with all applicable laws regarding purchase and use of these materials.

Important Regulatory Notice

These products are for research use only and are not intended for human consumption, therapeutic use, or diagnostic purposes. All compounds described herein have not been approved by the FDA for human use. These products are strictly intended for in vitro laboratory research and analytical purposes when conducted by qualified research professionals in licensed facilities. Users are responsible for ensuring compliance with all applicable laws regarding purchase and use of these materials.