Vesugen

Vesugen (Lys-Glu-Asp, or KED) is a synthetic tripeptide developed in Russia as part of a series of bioregulatory peptides studied for their tissue-specific effects on gene expression and cellular function, particularly in the vascular endothelium. Vesugen was designed to mimic short peptide signals that regulate chromatin activity and support vascular wall homeostasis. In preclinical research, it has been studied for its influence on endothelial cell biology, vessel tone regulation, and age-related vascular changes. Like other cytomedine-class peptides, Vesugen is examined for its ability to modulate protein synthesis in target tissues and has been investigated in models of cardiovascular aging and endothelial dysfunction. For research use only. Not for human consumption.

Chemical Structure and Identification

• Molecular Formula: C₁₅H₂₆N₄O₈
• Molecular Weight: 390.39 g/mol
• CAS Number: 204271-66-9

Research Applications

• Vascular Endothelial Biology: Investigation of Vesugen’s effects on endothelial cell gene expression, proliferative activity, and functional protein synthesis in vascular cell models [1]
• Aging and Cardiovascular Research: Study of KED tripeptide bioregulatory effects on age-related endothelial dysfunction, vessel wall remodeling, and inflammatory marker expression [2]
• Epigenetic Regulation Research: Examination of short peptide interactions with chromatin regulatory elements and histone-associated transcription modulation in vascular tissue models [3]
• Cytomedine Peptide Comparative Pharmacology: Use of Vesugen alongside other tissue-specific bioregulatory tripeptides to study organ-selective gene expression regulatory patterns [4]

Reference Citations

1. Khavinson VK et al. (2003) – Bull Exp Biol Med | https://pubmed.ncbi.nlm.nih.gov/14502318/
2. Khavinson VK et al. (2005) – Neuro Endocrinol Lett | https://pubmed.ncbi.nlm.nih.gov/16288196/
3. Vanyushin BF et al. (2005) – Biochemistry (Mosc) | https://pubmed.ncbi.nlm.nih.gov/15638569/
4. Linkova NS et al. (2012) – Bull Exp Biol Med | https://pubmed.ncbi.nlm.nih.gov/23113199/

Important Regulatory Notice

These products are for research use only and are not intended for human consumption, therapeutic use, or diagnostic purposes. All compounds described herein have not been approved by the FDA for human use. These products are strictly intended for in vitro laboratory research and analytical purposes when conducted by qualified research professionals in licensed facilities. Users are responsible for ensuring compliance with all applicable laws regarding purchase and use of these materials.