TB-500

TB-500 is a synthetic analogue of Thymosin Beta-4 (TB-4), a 43-amino acid peptide naturally present in nearly all nucleated mammalian cells at high concentrations. TB-500 is specifically studied for its role in actin monomer (G-actin) sequestration, cytoskeletal organization, and the regulation of cell migration. The peptide contains a conserved LKKTETQ actin-binding domain that is responsible for its effects on cellular motility, endothelial organization, and extracellular matrix remodeling. In preclinical research, TB-500 has demonstrated effects on wound closure, angiogenesis, inflammation reduction, and tissue regeneration across skin, cardiac, and neurological models. It exhibits a low molecular weight and lacks extracellular matrix binding, which facilitates broad tissue distribution in experimental systems. For research use only. Not for human consumption.

Chemical Structure and Identification

• Molecular Formula: C₂₁₂H₃₅₀N₅₆O₇₈S
• Molecular Weight: 4963.44 g/mol
• CAS Number: 77591-33-4

Research Applications

• Actin Dynamics and Cell Migration: Investigation of Thymosin Beta-4’s G-actin sequestration activity and its effects on cytoskeletal remodeling, lamellipodia formation, and directional cell migration in endothelial and fibroblast models [1]
• Wound Healing and Angiogenesis: Study of TB-500’s promotion of keratinocyte migration, endothelial tube formation, and collagen deposition in wound healing and vascular regeneration models [2]
• Cardiac Protection and Repair: Examination of Thymosin Beta-4’s cardioprotective effects in ischemia models, including cardiomyocyte survival, scar remodeling, and cardiac progenitor cell activation [3]
• Neurological Repair Research: Analysis of TB-500’s neuroprotective effects and its promotion of neuronal cell survival and axon outgrowth in central and peripheral nervous system injury models [4]

Reference Citations

1. Goldstein AL et al. (2012) – Ann N Y Acad Sci | https://pubmed.ncbi.nlm.nih.gov/22239444/
2. Philp D et al. (2004) – FASEB J | https://pubmed.ncbi.nlm.nih.gov/15001555/
3. Bock-Marquette I et al. (2004) – Nature | https://pubmed.ncbi.nlm.nih.gov/15343342/
4. PMC3872266 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3872266/

Important Regulatory Notice

These products are for research use only and are not intended for human consumption, therapeutic use, or diagnostic purposes. All compounds described herein have not been approved by the FDA for human use. These products are strictly intended for in vitro laboratory research and analytical purposes when conducted by qualified research professionals in licensed facilities. Users are responsible for ensuring compliance with all applicable laws regarding purchase and use of these materials.