Snap-8

SNAP-8 (Acetyl Glutamyl Heptapeptide-3) is a synthetic octapeptide with the sequence Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2 that mimics the N-terminal domain of SNAP-25, a component of the SNARE (Soluble NSF Attachment Protein REceptor) complex. By competing with SNAP-25 for positioning within the SNARE complex, SNAP-8 is studied for its ability to modulate neuromuscular junction signaling and acetylcholine-mediated vesicle fusion. In dermatological and cosmetic research, it has been investigated as a topical agent for studying the reduction of muscle-contraction-associated wrinkle formation. Preclinical and clinical studies have examined its ability to reduce the depth of expression lines through interference with synaptic vesicle release mechanisms. For research use only. Not for human consumption.

Chemical Structure and Identification

• Molecular Formula: C₄₁H₇₀N₁₆O₁₆S
• Molecular Weight: 1075.16 g/mol
• CAS Number: 868844-74-0

Research Applications

• SNARE Complex Biology: Investigation of SNAP-8’s competitive displacement of SNAP-25 within the SNARE complex and the downstream effects on vesicle fusion dynamics in neuronal cell models [1]
• Neuromuscular Junction Research: Study of acetylcholine release inhibition and its effects on muscle fiber contraction amplitude in controlled in vitro neuromuscular assay systems [2]
• Cosmetic and Dermatological Research: Examination of peptide-mediated wrinkle reduction in randomized, double-blind clinical study models evaluating expression line depth at 4, 8, and 12 weeks [3]
• Peptide Biomimetic Pharmacology: Analysis of SNAP-25-derived peptide fragments as pharmacological mimetics compared to botulinum toxin A in SNARE-targeted experimental systems [4]

Reference Citations

1. PubChem CID 86080331 | https://pubchem.ncbi.nlm.nih.gov/compound/86080331
2. Blanes-Mira C et al. (2002) – Int J Cosmet Sci | https://pubmed.ncbi.nlm.nih.gov/18494926/
3. PMC8211334 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8211334/
4. Kim SH et al. (2022) – J Cosmet Dermatol | https://pubmed.ncbi.nlm.nih.gov/36165538/

Important Regulatory Notice

These products are for research use only and are not intended for human consumption, therapeutic use, or diagnostic purposes. All compounds described herein have not been approved by the FDA for human use. These products are strictly intended for in vitro laboratory research and analytical purposes when conducted by qualified research professionals in licensed facilities. Users are responsible for ensuring compliance with all applicable laws regarding purchase and use of these materials.