KissPeptin-10

Kisspeptin-10 (KP-10) is a decapeptide derived from the proteolytic cleavage of the Kiss1 gene-encoded precursor protein kisspeptin-54. It represents the shortest bioactive fragment of the kisspeptin family and binds with high affinity to the G-protein-coupled receptor GPR54 (also known as KISS1R), triggering intracellular signaling cascades including IP3-mediated calcium mobilization and PKC activation. Kisspeptin-10 plays a recognized role in the hypothalamic regulation of gonadotropin-releasing hormone (GnRH) secretion, making it a key research tool in reproductive endocrinology. It has also been studied in the context of tumor suppression, osteoblast differentiation, and peripheral vascular biology. This product is for laboratory research use only and is not intended for human consumption.

Chemical Structure and Identification

• Molecular Formula: C₆₃H₈₃N₁₇O₁₄
• Molecular Weight: 1302.45 g/mol
• CAS Number: 374675-21-5

Research Applications

• Reproductive Endocrinology: Study of kisspeptin-10’s role in GPR54-mediated GnRH pulse regulation, LH surge induction, and hypothalamic-pituitary-gonadal axis signaling in rodent models [1]
• Tumor Suppression Research: Examination of kisspeptin’s role as a metastasis suppressor through KISS1 gene activity in cancer cell migration and invasion assays [2]
• Bone Biology: Investigation of KP-10’s effects on osteoblast differentiation via GPR54-mediated BMP2 upregulation and Smad1/5/9 phosphorylation pathways [3]
• Vascular Biology: Analysis of kisspeptin-10’s vasoconstrictor and vascular permeability effects in cutaneous microvascular models [4]

Reference Citations

1. Dhillo WS et al. (2005) – J Clin Endocrinol Metab | https://pubmed.ncbi.nlm.nih.gov/16293695/
2. Lee JH et al. (1996) – J Natl Cancer Inst | https://pubmed.ncbi.nlm.nih.gov/8666658/
3. PMC10855899 | https://pmc.ncbi.nlm.nih.gov/articles/PMC10855899/
4. Sawyer I et al. (2011) – PLoS One | https://pmc.ncbi.nlm.nih.gov/articles/PMC3036649/

Important Regulatory Notice

These products are for research use only and are not intended for human consumption, therapeutic use, or diagnostic purposes. All compounds described herein have not been approved by the FDA for human use. These products are strictly intended for in vitro laboratory research and analytical purposes when conducted by qualified research professionals in licensed facilities. Users are responsible for ensuring compliance with all applicable laws regarding purchase and use of these materials.