Epithalon

Epithalon, a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly, was discovered by Russian scientist Vladimir Khavinson. This peptide, derived from the polypeptide Epithalamin found in the pineal gland, is of interest for its role in regulating telomerase expression, which is key to telomere maintenance. Research has explored Epithalon’s effects on oxidative stress, neuronal survival, circadian rhythms, and immune modulation, making it a valuable subject for studies in aging and neurodegeneration.

Free Shipping on orders over $200

Epithalon (also known as Epitalon or Epithalone) is a synthetic tetrapeptide with the amino acid sequence Ala-Glu-Asp-Gly, originally discovered by the Russian scientist Vladimir Khavinson. The peptide is a fragment of the polypeptide Epithalamin, which is extracted from the pineal gland and has been studied for its potential anti-aging and neuroprotective properties. Epithalon has been shown to regulate the expression of telomerase, an enzyme responsible for maintaining the length of telomeres, which play a crucial role in cellular aging and senescence. In vitro and animal studies have demonstrated Epithalon’s ability to increase telomere length, reduce the accumulation of oxidative stress-induced damage, and promote the survival of neurons under stressful conditions. The peptide has also been investigated for its effects on circadian rhythm regulation, melatonin production, and immune system modulation. Epithalon’s multiple biological activities and potential geroprotective effects make it a promising candidate for research in the fields of aging, neurodegeneration, and regenerative medicine.

Chemical Structure and Identification

  • Molecular Formula: C₁₄H₂₂N₄O₉
  • Molecular Weight: 390.35 g/mol
  • CAS Number: 307297-39-8

Research Applications

  • Telomere and Telomerase Regulation: Investigation of Epithalon’s effects on telomere length maintenance and cellular senescence pathways [1]
  • Neuroprotection and Neuroregeneration: Examination of the peptide’s ability to promote neuronal survival and regeneration in models of neurodegenerative diseases [2]
  • Oxidative Stress Modulation: Study of Epithalon’s antioxidant properties and its role in reducing oxidative damage accumulation in aging models [3]
  • Circadian Rhythm and Melatonin Regulation: Exploration of the peptide’s influence on pineal gland function, melatonin secretion, and sleep-wake cycles [4]
  • Immune System Modulation: Investigation of Epithalon’s effects on immune cell function, cytokine production, and immunosenescence in aging models [1]

Reference Citations

  1. Khavinson VK et al. (2020) – Aging (Albany NY) | https://pubmed.ncbi.nlm.nih.gov/32229705/
  2. PMC6826135 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6826135/
  3. Khavinson VK et al. (2019) – Curr Aging Sci | https://pubmed.ncbi.nlm.nih.gov/30767749/
  4. Korkushko OV et al. (2004) – Bull Exp Biol Med | https://pubmed.ncbi.nlm.nih.gov/15389041/

Important Regulatory Notice

These products are for research use only and are not intended for human consumption, therapeutic use, or diagnostic purposes. All compounds described herein have not been approved by the FDA for human use. These products are strictly intended for in vitro laboratory research and analytical purposes when conducted by qualified research professionals in licensed facilities. Users are responsible for ensuring compliance with all applicable laws regarding purchase and use of these materials.

Important Regulatory Notice

These products are for research use only and are not intended for human consumption, therapeutic use, or diagnostic purposes. All compounds described herein have not been approved by the FDA for human use. These products are strictly intended for in vitro laboratory research and analytical purposes when conducted by qualified research professionals in licensed facilities. Users are responsible for ensuring compliance with all applicable laws regarding purchase and use of these materials.