AOD-9604

AOD9604 is a synthetic peptide fragment derived from the C-terminus of human growth hormone (hGH) that has been researched for its potential fat-reducing effects without the diabetogenic and proliferative properties of the full hGH protein. The peptide comprises amino acids 177-191 of hGH and has been shown to stimulate lipolysis and inhibit lipogenesis both in vitro and in animal studies. AOD9604 appears to induce fat loss through the stimulation of beta-3 adrenoreceptors, which promote the breakdown of stored triglycerides in adipocytes. Preclinical research indicates that AOD9604 may also influence fat metabolism and energy expenditure through interactions with hypothalamic pathways. The peptide’s targeted activity and limited side effect profile compared to full-length hGH make it a valuable tool for investigating obesity mechanisms and metabolic regulation.

Chemical Structure and Identification

• Molecular Formula: C₇₂H₁₁₅N₂₁O₂₀
• Molecular Weight: 1558.81 g/mol
• CAS Number: 221231-10-3

Research Applications

• Lipolysis and Fat Metabolism: Investigation of AOD9604’s effects on triglyceride breakdown and fatty acid oxidation in adipocytes [1]
• Energy Expenditure: Examination of AOD9604’s impact on metabolic rate and thermogenesis in preclinical models [2]
• Hypothalamic Signaling: Exploration of AOD9604’s interactions with central pathways regulating appetite and energy balance [3]
• Growth Hormone Fragment Activity: Comparative studies on the metabolic effects of AOD9604 versus full-length hGH [1]

Reference Citations

1. PMC2804956 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2804956/
2. Stier U et al. (2019) – J Cachexia Sarcopenia Muscle | https://pubmed.ncbi.nlm.nih.gov/30680949/
3. Heffernan MA et al. (2001) – Endocrinology | https://pubmed.ncbi.nlm.nih.gov/11606464/

Important Regulatory Notice

These products are for research use only and are not intended for human consumption, therapeutic use, or diagnostic purposes. All compounds described herein have not been approved by the FDA for human use. These products are strictly intended for in vitro laboratory research and analytical purposes when conducted by qualified research professionals in licensed facilities. Users are responsible for ensuring compliance with all applicable laws regarding purchase and use of these materials.