Semax (Spray)

Semax is a synthetic heptapeptide derived from the ACTH fragment ACTH(4-7), featuring an added Pro-Gly-Pro sequence at the C-terminus. Designed to enhance the properties of the parent fragment, Semax effectively crosses the blood-brain barrier and engages central nervous system signaling pathways. This peptide is known for its role in stimulating the release of brain-derived neurotrophic factor (BDNF) and has been studied for its effects on brain cortex tissue transcriptomes and interaction with amyloid-beta oligomers.

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Semax is a synthetic heptapeptide derived from the adrenocorticotropic hormone (ACTH) fragment ACTH(4-7), with an additional Pro-Gly-Pro tripeptide sequence appended at the C-terminus. Developed to enhance the nootropic and neuroprotective properties of the parent ACTH fragment, Semax exhibits the ability to cross the blood-brain barrier and directly engage central nervous system signaling pathways. The peptide stimulates the release of brain-derived neurotrophic factor (BDNF), a protein critical for neuronal survival, synaptic plasticity, and neurogenesis. Research has demonstrated Semax activity in modulating brain cortex tissue transcriptomes and interacting with amyloid-beta oligomers.

Chemical Structure and Identification

Molecular Formula: C₃₆H₅₄N₁₀O₁₀S
Molecular Weight: 813.92 g/mol
CAS Number: 80714-61-0

Research Applications

BDNF Signaling Research: Investigation of Semax’s effects on brain-derived neurotrophic factor release and synaptic plasticity [1]
Neuroprotection Mechanisms: Examination of Semax’s impact on ischemia-related gene expression and cortical protection [2]
Neuroplasticity Pathways: Study of Semax’s influence on synaptic signaling and cognitive function mechanisms [3]
Transcriptome Regulation: Exploration of Semax’s effects on immune response and neuroprotective gene expression patterns [4]

Reference Citations

Dolotov OV et al. (2006) – Brain Res | https://pubmed.ncbi.nlm.nih.gov/
PMC3113378 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3113378/
PubChem CID 9811102 | https://pubchem.ncbi.nlm.nih.gov/compound/9811102
PMC5514390 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5514390/

Important Regulatory Notice

These products are for research use only and are not intended for human consumption, therapeutic use, or diagnostic purposes. All compounds described herein have not been approved by the FDA for human use. These products are strictly intended for in vitro laboratory research and analytical purposes when conducted by qualified research professionals in licensed facilities. Users are responsible for ensuring compliance with all applicable laws regarding purchase and use of these materials.