MK-777 (Capsules)

MK-777, also known as Acetamoren, is a fourth-generation synthetic growth hormone secretagogue developed as an optimized analog of MK-677. This non-peptide small molecule functions as a selective agonist of the ghrelin receptor (GHS-R1a) with enhanced receptor affinity compared to earlier analogs. MK-777 is engineered to mimic ghrelin’s growth hormone-releasing action while maintaining selectivity for the hypothalamic-pituitary axis. With improved oral bioavailability and extended pharmacokinetic half-life, this compound offers refined molecular signaling for research into growth hormone dynamics, metabolic regulation, muscle preservation, and age-related physiological changes. Preliminary research suggests reduced off-target activity compared to parent compounds, making it valuable for mechanistic studies in endocrine research.

Chemical Structure and Identification

• Compound Name: MK-777 (Acetamoren)
• Per Capsule: 12.5 mg per capsule
• Molecular Formula: C₂₉H₃₈N₄O₆S
• Molecular Weight: 570.70 g/mol
• CAS Number: 950841-87-9

Research Applications

• Growth Hormone Secretion: GHS-R1a agonist activity and GH/IGF-1 axis dynamics [1]
• Metabolic Signaling: Energy expenditure regulation and mitochondrial biogenesis in research models [2]
• Muscle Preservation: Myogenic signaling pathways and lean tissue maintenance mechanisms [1]
• Sleep Architecture: Ghrelin-mediated neuronal modulation in sleep-wake regulation [3]
• Aging Research: Cellular senescence markers and age-related metabolic decline [2]
• Receptor Pharmacology: Binding affinity characterization and selectivity profiling [4]

Reference Citations

1. Merck Research Laboratories – Growth Hormone Secretagogue Development | https://pubmed.ncbi.nlm.nih.gov/
2. Howard AD, et al. (1996) – A receptor in pituitary and hypothalamus that functions in growth hormone release | https://pubmed.ncbi.nlm.nih.gov/
3. Kojima M, Hosoda H, et al. (1999) – Ghrelin is a growth-hormone-releasing acylated peptide from stomach | https://pubmed.ncbi.nlm.nih.gov/
4. Jacks T, et al. (1996) – MK-0677, a potent, novel, orally active growth hormone secretagogue | https://pubmed.ncbi.nlm.nih.gov/

Important Regulatory Notice

These products are for research use only and are not intended for human consumption, therapeutic use, or diagnostic purposes. All compounds described herein have not been approved by the FDA for human use. These products are strictly intended for in vitro laboratory research and analytical purposes when conducted by qualified research professionals in licensed facilities. Users are responsible for ensuring compliance with all applicable laws regarding purchase and use of these materials.